I wrote a simple background with the flask framework, the project is written by pycharm, the virtual environment is automatically configured by pycharm when developing, and the project directory is as follows.

• app

  • _ _ init__.py

  • match

    • _ _ init__.py
    • views.py

  • user

    • _ _ init__.py
    • views.py
• static
• venv
• config.py
• manage.py

match and user are two blueprints, and app runs in the top-level manage.py.
there is no problem with the development. Pycharm can debug normally, but there is a problem when preparing to deploy to the server.
is deployed in the way of Nginx + uWSGI. After I download the directory to the server with git, I create a new virtual environment

pip install -r requirtment.txt

installation depends on the environment. The contents of the file are as follows:

aniso8601==3.0.0
certifi==2018.4.16
chardet==3.0.4
click==6.7
crcmod==1.7
Flask==0.12.2
Flask-RESTful==0.3.6
Flask-SQLAlchemy==2.3.2
idna==2.6
itsdangerous==0.24
Jinja2==2.10
MarkupSafe==1.0
oss2==2.4.0
PyMySQL==0.8.0
pytz==2018.4
requests==2.18.4
six==1.11.0
SQLAlchemy==1.2.6
urllib3==1.22
Werkzeug==0.14.1

the new configuration file for pip installation uwsgi, after installation is as follows:

[uwsgi]
socket = 127.0.0.1:8000

-sharp 
chdir = /data/Dudu/
plugins=python34

home = /data/Dudu/env/
vhost = true

no-site=true

-sharp flask
wsgi-file =manage.py

-sharp flaskmanage.pyapp
callable = app

-sharp 
processes = 1

-sharp 
threads = 2

-sharp

uid = root
gid = root

nginx is previously configured and can jump 502.
error running uwsgi,
pythonpath=/data/Dudu/env/lib/python3.4/site-packages

*** Operational MODE: threaded ***
Traceback (most recent call last):
  File "manage.py", line 1, in <module>
    from app import app_create
  File "./app/__init__.py", line 1, in <module>
    from flask import Flask
ImportError: No module named "flask"
unable to load app 0 (mountpoint="") (callable not found or import error)

various queries, add a setting:
added / data/Dudu/env/lib/python3.4/site-packages/ to pythonpath.
still report an error:

added /data/Dudu/env/bin/python3 to pythonpath.
Traceback (most recent call last):
  File "manage.py", line 1, in <module>
    from app import app_create
  File "./app/__init__.py", line 1, in <module>
    from flask import Flask
  File "/data/Dudu/env/lib/python3.4/site-packages/flask/__init__.py", line 17, in <module>
    from werkzeug.exceptions import abort
  File "/data/Dudu/env/lib/python3.4/site-packages/werkzeug/__init__.py", line 151, in <module>
    __import__("werkzeug.exceptions")
  File "/data/Dudu/env/lib/python3.4/site-packages/werkzeug/exceptions.py", line 67, in <module>
    from werkzeug._internal import _get_environ
  File "/data/Dudu/env/lib/python3.4/site-packages/werkzeug/_internal.py", line 12, in <module>
    import string
ImportError: No module named "string"
unable to load app 0 (mountpoint="") (callable not found or import error)

I have seen the answers to almost all the related questions in the past two days, and all kinds of packages in the virtual environment have also been installed and installed, but they are still unsolved. The server is a centos,python3.4/2.7 environment, before running a flask project, can run normally, now just can not find the flask module, really fascinated. I hope you can give us your advice.
manage.py:

from app import app_create
app=app_create()


if __name__ == "__main__":
    app.run(port = 8000)
~

app/__init__.py

from flask import Flask
import config
from .models import db

def app_create():
    from .match  import match as  match_blueprint
    from .user   import user  as  user_blueprint
    app = Flask(__name__)
    app.config.from_object(config)
    app.secret_key="1234"
    db.init_app(app)
    app.register_blueprint(match_blueprint)
    app.register_blueprint(user_blueprint)
    return app
~

Boss, help rookies, thank you very much